The Nobel Academy noted that Caroline Bertozzi expanded click chemistry to a new level and started applying it to living organisms. They added that Barry Sharpless and Morten Milldahl laid the groundwork for a functional form of chemistry in which molecular building blocks stick together quickly and effectively.
According to the Nobel statement, “Chemists have long been motivated by the urge to develop increasingly complex compounds.”
In pharmaceutical research, this often involves reconstitution of natural molecules with medicinal properties. This has resulted in many wonderful molecular structures, but they are very time-consuming and expensive to produce.
Interestingly, scientist Barry Sharpless previously won the Nobel Prize in Chemistry in 2000.
Chaples developed the concept of click chemistry, a form of simple and reliable chemistry in which reactions occur quickly and unwanted by-products are avoided.
Then, unrelated to one another, Morten Meldahl and Barry Sharpless introduced the azide-alkyne cycloaddition of catalysed copper, which has been referred to as the jewel in the crown of tap chemistry. Today, it is a common practise to map DNA using an efficient chemical reaction in order to generate medications and better materials.
Theodora R.
To map crucial and elusive macromolecules on the surface of cells, called glycans, Bertozzi has devised click reactions that function inside living organisms, where their orthogonal biological interactions take place without interfering with the natural chemistry of the cell.
Today, scientists around the world employ these interactions to investigate cells and track biological processes.
Researchers have enhanced the targeting of cancer medications via orthogonal interactions, and these drugs are currently being examined in clinical studies.
Someone took home the prize a second time. Three people who created the scientific crown jewels received the Nobel Prize in Chemistry.
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